"Nobody wants to die, but nature says, "You must die." Where is your independence? Nobody wants to take birth, enter into the mother's womb, but you must enter. Nobody wants to become old man. Nature says, "You must become old man." Nobody wants disease.
The nature says, "You must have disease." So where is your independence? But the crazy fellow says, "I am independent. I think like this." What is the value of your thinking? You may think in your favor, but the nature will not allow you. So everyone is crazy who is declaring independence."
{Lecture by Srila Prabhupada,BG 09.04 - Melbourne - April 23, 1976}